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Updated: Jan 30, 2026

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
Clostridium sporogenes bacteremia in an immunocompetent patient
Waiel Abusnina1, Mena Shehata2, Emhemmid Karem1
1Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia 25701, USA.
Abstract:
Of the 200 Clostridium spp. known to exist, approximately 30 have been associated with human disease. Commonly found in soil, marine sediment and mammalian intestinal tracts, these gram-positive bacilli are known to cause infections ranging from cellulitis to septicemia. Isolates that are identified by clinical microbiology laboratories include Clostridium perfrigens species in 20-40% of cases. However, when Clostridium sporogenes is identified, is rarely considered to be pathogenic. We present a case of Clostridium sporogenes bacteremia secondary to lower limb cellulitis and osteomyelitis in an immunocompetent patient.
Insights
This study reports a rare case of Clostridium sporogenes bacteremia in an immunocompetent patient. This finding highlights the potential pathogenicity of C. sporogenes, previously considered non-pathogenic.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Clinical Case Study
Background:
- Clostridium species are gram-positive bacilli found in various environments, including soil and mammalian intestines.
- While some Clostridium species cause significant human disease, Clostridium sporogenes is rarely considered pathogenic.
- Clinical microbiology laboratories frequently identify Clostridium species, with Clostridium perfringens being common.
Purpose of the Study:
- To present a case of Clostridium sporogenes bacteremia.
- To highlight a rare instance of C. sporogenes infection in an immunocompetent individual.
- To discuss the potential pathogenicity of C. sporogenes.
Main Methods:
- Case report presentation.
- Identification of Clostridium sporogenes from patient isolates.
- Clinical and microbiological assessment of a lower limb infection.
Main Results:
- Clostridium sporogenes bacteremia was diagnosed.
- The infection was secondary to lower limb cellulitis and osteomyelitis.
- The patient was immunocompetent, indicating infection in a non-compromised host.
Conclusions:
- Clostridium sporogenes can be pathogenic and cause serious infections like bacteremia.
- This case underscores the importance of considering C. sporogenes in the differential diagnosis of infections, even in immunocompetent patients.
- Further investigation into the pathogenic potential of C. sporogenes is warranted.
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