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Isolation and Characterization of Microvesicles from Peripheral Blood
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Circulating microvesicles in snakebite patients with microangiopathy.

Anoop K Enjeti1,2,3,4,5, Lisa F Lincz1,4,5,6, Michael Seldon1,2,3

  • 1Department of Haematology Calvary Mater Newcastle Waratah New South Wales Australia.

Research and Practice in Thrombosis and Haemostasis
|January 19, 2019
PubMed
Summary
This summary is machine-generated.

Red blood cell microvesicles (MV) are elevated in snakebite patients with microangiopathic hemolytic anemia (MAHA). Measuring these red cell MV may help predict MAHA in snakebite victims.

Keywords:
coagulopathyextracellular vesiclesmicroangiopathymicrovesiclessnakebitevenom

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Area of Science:

  • Hematology
  • Toxicology
  • Immunology

Background:

  • Snake envenoming frequently causes consumption coagulopathy, leading to hemorrhage, microangiopathic hemolytic anemia (MAHA), acute kidney injury, and thrombocytopenia.
  • The specific role of circulating microvesicles (MV) in snakebite patients has not been previously explored.

Purpose of the Study:

  • To investigate and compare circulating MV subsets in snakebite patients with venom-induced consumption coagulopathy, with or without MAHA, against healthy controls.
  • To determine if MV levels can serve as predictive markers for MAHA in snakebite cases.

Main Methods:

  • Samples from snake envenomed patients (brown snakes, tiger snakes, taipans) were analyzed.
  • Flow cytometry was used to quantify platelet (CD41a), endothelial (CD62e), and red cell (glycophorin) MV.
  • Coagulation parameters and blood films were assessed for hemolysis.

Main Results:

  • Red cell MV levels were significantly higher in snakebite patients with MAHA compared to those without MAHA.
  • Platelet MV levels did not differ significantly between snakebite patients with and without MAHA.
  • Endothelial MV levels were reduced in all snakebite patients compared to controls.

Conclusions:

  • Elevated red cell MV at presentation may serve as a predictive marker for MAHA in snakebite patients.
  • Further research into MV's role in envenoming pathophysiology is warranted.