RANKL is associated with persistent primary teeth and delayed permanent tooth emergence
Juliana Arid1, Thaís Aparecida Xavier1, Raquel Assed Bezerra da Silva1
1Department of Pediatric Dentistry, University of São Paulo - School of Dentistry of Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.
International Journal of Paediatric Dentistry
|January 19, 2019
Summary
Genetic variations in RANKL are linked to delayed permanent tooth eruption. Lower RANKL gene expression in dental tissue is associated with persistent primary teeth, impacting overall tooth development.
Area of Science:
- Genetics
- Developmental Biology
- Pediatric Dentistry
Background:
- Tooth eruption is a complex biological process with incompletely understood mechanisms.
- The RANK/RANKL/OPG pathway plays a crucial role in bone remodeling and tooth development.
Purpose of the Study:
- To investigate the association between genetic polymorphisms in the RANK/RANKL/OPG system and delayed tooth emergence.
- To examine the correlation between the gene expression of RANK/RANKL/OPG and the persistence of primary teeth.
Main Methods:
- Saliva samples from 160 children (6-13 years) were analyzed for genetic polymorphisms.
- Periapical tissue from 15 children with persistent primary teeth and 15 controls underwent qPCR analysis for gene expression.
Main Results:
- A significant association was found between the T allele of RANKL (rs9594738) and increased risk of delayed tooth emergence (OR=1.71).
- Children with delayed emergence and persistent primary teeth exhibited lower relative gene expression of RANKL and a lower RANKL/OPG ratio compared to controls.
Conclusions:
- The rs9594738 polymorphism in RANKL is implicated in delayed permanent tooth emergence.
- Reduced RANKL gene expression in periapical tissues is linked to the retention of primary teeth.
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