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Updated: Jan 30, 2026

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
Comorbidities in elderly patients with glioblastoma: a field-practice study
Veronica Villani1, Antonio Tanzilli1, Stefano M Telera2
1Neuro-Oncology Unit, 'Regina Elena' National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Aim:
This single-center study evaluated the effect of comorbidities on progression-free and overall survival in elderly patients with glioblastoma multiforme (GBM).
Patients & Methods:
Comorbid conditions were identified in each patient with the modified version of the cumulative illness rating scale (CIRS).
Results:
Total of 118 patients with GBM were enrolled. An age of >75 years at diagnosis, high CIRS, comorbidity index and performance status play a predictive role on survival.
Conclusion:
Comorbidities play an important prognostic role in elderly patients with GBM, a factor too often neglected in clinical practice. If the prognostic role of comorbidity measured by CIRS on outcome will be confirmed, it would be interesting to add it in the algorithm for treatment choice in elderly GBM patients.
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