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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study
Andrea Silvestrini1, Carmine Bruno2, Edoardo Vergani2
1Institute of Biochemistry and Clinical Biochemistry, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma-Università Cattolica del Sacro Cuore, Roma, Italy.
Plos One
|January 19, 2019
Summary
Irisin levels are higher in heart failure with preserved ejection fraction (HFpEF) than in heart failure with reduced ejection fraction (HFrEF). Oxidative stress influences irisin secretion differently in these heart failure subtypes.
Area of Science:
- Cardiology
- Endocrinology
- Biochemistry
Background:
- Irisin, a myokine, is a potential prognostic factor in cardiovascular diseases.
- Limited data exist on irisin's role in heart failure (HF), specifically HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF).
Purpose of the Study:
- To evaluate circulating irisin levels in HFpEF and HFrEF patients.
- To correlate irisin levels with metabolic parameters and total antioxidant capacity (TAC) as an indicator of oxidative stress.
Main Methods:
- Measurement of serum irisin levels in HFpEF and HFrEF cohorts.
- Correlation analysis with HOMA index and TAC.
Main Results:
- Irisin levels were significantly higher in HFpEF patients (7.72 ± 0.76 ng/ml) compared to HFrEF patients (2.77 ± 0.77 ng/ml).
- An inverse correlation between irisin and TAC was observed in HFpEF, but not in HFrEF.
- No correlation was found between irisin and HOMA index in either group.
Conclusions:
- Distinct pathophysiological mechanisms may underlie HFpEF and HFrEF.
- Oxidative stress appears to modulate irisin secretion differently across HF subtypes.
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