Related Experiment Video
Updated: Jan 30, 2026
14:04
Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
Published on: March 25, 2016
15.8K
Development of new agents for peripheral T-cell lymphoma
Yuta Ito1, Shinichi Makita1, Kensei Tobinai1
1a Department of Hematology , National Cancer Center Hospital , Tokyo , Japan.
Expert Opinion on Biological Therapy
|January 19, 2019
Summary
Novel agents offer promising therapeutic options for relapsed/refractory Peripheral T-cell lymphoma (PTCL), but combination therapies and immune strategies are crucial for improved outcomes.
Area of Science:
- Hematology
- Oncology
- Pharmacology
Background:
- Peripheral T-cell lymphoma (PTCL) is a rare and aggressive T-cell neoplasm.
- PTCL often shows refractoriness to conventional chemotherapy, leading to poor prognoses.
Purpose of the Study:
- To review approved novel agents and those under clinical development for PTCL.
- To discuss future directions in PTCL treatment, including combination therapies and immunotherapy.
Main Methods:
- Review of approved agents such as pralatrexate, belinostat, romidepsin, and brentuximab vedotin.
- Summary of agents approved in Asian countries, including mogamulizumab, chidamide, and forodesine.
- Analysis of ongoing clinical development for new PTCL therapies.
Main Results:
- Several novel agents have been approved globally for PTCL treatment.
- Approved agents include dihydrofolate reductase inhibitors, histone deacetylase inhibitors, and antibody-drug conjugates.
- Agents like mogamulizumab and chidamide are approved in specific Asian regions.
Conclusions:
- Novel agents represent a significant advancement for relapsed/refractory PTCL.
- Current novel agents are not curative as monotherapy.
- Future research should focus on combination therapies, novel-novel combinations, immunotherapy (e.g., CAR T-cell therapy), and predictive marker analysis.
Related Concept Videos
01:29Subviral Agents
559
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
559
01:27Air-entraining Agents
270
Air-entraining agents improve the durability and workability of concrete in climates with frequent freezing and thawing. These agents prevent cracks by introducing small air bubbles into the mix, creating spaces accommodating water expansion when temperatures drop. The air-entraining agents lower the surface tension of water, forming stable, small air bubbles. This method is more effective than having accidental large voids, as the intentional, smaller, and evenly distributed air voids improve...
270
01:10Zygotic Development And Stem Cell Formation
6.7K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
6.7K
01:19Masking and Demasking Agents
3.6K
EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
3.6K
01:43Sustainable Development
15.1K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.1K
01:29Spasmolytic Agents: Chemical Classification
1.3K
Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
1.3K