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Updated: Jan 30, 2026

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
Published on: May 2, 2025
Revisiting IDO and its value as a predictive marker for anti-PD-1 resistance
Peter Kim Moon1, Stephanie Tran2, Paras Singh Minhas2
1Department of Neurology and Neurological Sciences, Stanford University, 1201 Welch Road, MSLS P250, Stanford, CA, 94305, USA. pkmoon@stanford.edu.
Abstract:
Botticelli et al. proposed the activity of indoleamine-2,3-dioxygenase 1 (IDO) as a potential mechanism and predictive marker for primary resistance against anti-PD-1 treatment in the context of non-small cell lung cancer. However, there are a few points for the authors to address in order to strengthen their claims. First, there are many enzymes that modulate the kynurenine to tryptophan ratio, thereby calling into question their use of the ratio as a proxy for IDO activity. Second, the authors could compare IDO to other proposed markers in the literature, providing a better understanding of its predictive value.
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