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Clinical Manifestations.

Stephanie Tran1, Niyatee Samudra2

  • 1Stanford, Palo Alto, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Ambulatory EEGs can detect subtle seizures in neurodegenerative diseases, aiding diagnosis and management. This study analyzes their utility in patients with mild cognitive impairment or dementia.

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Area of Science:

  • Neurology
  • Neuroscience
  • Medical Diagnostics

Background:

  • Subtle seizures and epileptiform discharges are common in neurodegenerative diseases.
  • Patients with neurodegenerative disorders often experience unexplained cognitive fluctuations.
  • Ambulatory electroencephalograms (EEGs) offer prolonged monitoring, increasing the detection rate of epileptiform abnormalities.

Purpose of the Study:

  • To evaluate the diagnostic yield and clinical impact of ambulatory EEGs in patients over 45 with mild cognitive impairment (MCI) or dementia.
  • To identify predictors of epileptiform abnormalities on ambulatory EEG in this population.
  • To assess whether ambulatory EEG findings change clinical management.

Main Methods:

  • Retrospective analysis of approximately 450 ambulatory EEG studies conducted between January 2023 and December 2024.
  • Inclusion criteria: patients over 45 with diagnosed MCI or dementia.
  • Data abstracted included indications for EEG, duration, abnormalities, and management changes; predictors of abnormalities and management impact were evaluated.

Main Results:

  • The study is expected to yield valuable data on the effectiveness of ambulatory EEG in detecting epileptiform abnormalities in neurodegenerative disease.
  • Results will inform the utility of prolonged EEG monitoring in patients with cognitive decline.

Conclusions:

  • Findings may help establish guidelines for using ambulatory EEGs in neurodegenerative disease patients, especially those with fluctuating cognition.
  • Clarifying indications for prolonged EEG can improve diagnostic accuracy and patient care.