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Drug Development.

Mina Kmiecik1, Minhtrang Chu1, Annie Zhou1

  • 1Stanford University, PALO ALTO, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
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Summary
This summary is machine-generated.

This study investigates bumetanide for Alzheimer's disease (AD). Early data suggests bumetanide may lower AD prevalence, prompting this clinical trial to assess its safety and efficacy in AD patients.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Trials

Background:

  • Bumetanide, an FDA-approved diuretic, is being explored for Alzheimer's disease (AD) repurposing.
  • Preclinical and Electronic Health Record (EHR) data suggest bumetanide may reduce AD prevalence.
  • Randomized controlled trials are necessary to confirm bumetanide's safety and efficacy in AD.

Purpose of the Study:

  • To evaluate the safety and tolerability of bumetanide in patients with biomarker-confirmed Alzheimer's disease.
  • To assess the clinical and biomarker effects of bumetanide in individuals with mild cognitive impairment or mild dementia due to AD.

Main Methods:

  • Phase II, randomized, double-blind, multi-arm, placebo-controlled, parallel-group study.
  • Participants with biomarker-confirmed AD, mild cognitive impairment, or mild dementia due to AD.
  • Evaluation of safety, tolerability, clinical outcomes, and biomarkers.

Main Results:

  • Study protocol and design presented for a Phase II trial.
  • Inclusion criteria focus on mild cognitive impairment or mild dementia due to AD.
  • Exclusion criteria address specific health conditions and concomitant medications.

Conclusions:

  • Presents the clinical trial protocol for a Phase II study of bumetanide in Alzheimer's disease.
  • Highlights the need for rigorous clinical evaluation of bumetanide's therapeutic potential in AD.