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Updated: Jan 30, 2026

Analysis and Specification of Starch Granule Size Distributions
Published on: March 4, 2021
Novel pH-responsive granules with tunable volumes from oxidized corn starches
1Department of Agricultural Chemistry, National Taiwan University No. 1, Roosevelt Rd., Sec. 4, Taipei 10617, Taiwan.
Novel pH-responsive starch granules were developed using TEMPO-mediated oxidation and pregelatinization. These modified granules exhibit tunable volume and potential for controlled active compound delivery.
Area of Science:
- Materials Science
- Biochemistry
- Polymer Chemistry
Background:
- Starch granules are abundant biopolymers with potential for functional modification.
- Developing pH-responsive materials is crucial for targeted delivery systems.
Purpose of the Study:
- To prepare novel pH-responsive granules from oxidized starch with tunable volume.
- To explore their potential for active compound delivery applications.
Main Methods:
- TEMPO-mediated oxidation of waxy and normal corn starches to introduce carboxylate groups.
- Pregelatinization of oxidized starch granules to control swelling properties.
- Fourier transform infrared spectroscopy and thermogravimetric analysis for characterization.
Main Results:
- Successfully synthesized TEMPO-oxidized waxy and normal corn starch granules (TWSG and TNSG) with 9-10% oxidation.
- TWSG and TNSG showed significantly higher swelling ratios at pH 7 compared to pH 2, indicating pH-responsivity.
- Swelling ratios at pH 7 were 31.6 and 25.0 for TWSG and TNSG, respectively.
Conclusions:
- The prepared oxidized starch granules exhibit tunable volume and significant pH-responsivity.
- These materials show promise for applications in active compound delivery systems.
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