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Updated: Jan 30, 2026
In Vivo Two-photon Imaging Of Experience-dependent Molecular Changes In Cortical Neurons
Published on: January 5, 2013
Molecular tools for imaging and recording neuronal activity
Wenjing Wang1,2,3, Christina K Kim1, Alice Y Ting4,5
1Departments of Genetics, Biology, and Chemistry, Stanford University, Stanford, CA, USA.
Abstract:
To understand how the brain relates to behavior, it is essential to record neural activity in awake, behaving animals. To achieve this goal, a large variety of genetically encoded sensors have been developed to monitor and record the series of events following neuronal firing, including action potentials, intracellular calcium rise, neurotransmitter release and immediate early gene expression. In this Review, we discuss the existing genetically encoded tools for detecting and integrating neuronal activity in animals and highlight the remaining challenges and future opportunities for molecular biologists.
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