Patterns in anticoagulant utilization in the Czech Republic during 2007-2017
J Maly1, S Dvorackova1, E Zimcikova1
1Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, 500 05, Hradec Kralove, Czech Republic.
Journal of Thrombosis and Thrombolysis
|January 20, 2019
Summary
Direct oral anticoagulants (DOACs) are increasingly used in the Czech Republic, driving up costs. Their rising use has significantly impacted warfarin consumption and overall anticoagulant expenditures.
Area of Science:
- Pharmacoeconomics
- Clinical Pharmacy
- Drug Utilization Research
Background:
- Direct oral anticoagulants (DOACs) have been available in the Czech Republic since 2008 as alternatives to traditional anticoagulants.
- Vitamin K antagonists and parenteral anticoagulants have been the standard treatments prior to the introduction of DOACs.
Purpose of the Study:
- To evaluate drug use and expenditure patterns of anticoagulants in the Czech Republic.
- To analyze the market penetration and economic impact of DOACs compared to older anticoagulants.
Main Methods:
- Retrospective drug utilization study using data from the State Institute for Drug Control.
- Analysis of drug supplies based on Anatomical Therapeutic Chemical (ATC) codes B01AA, B01AB, B01AE, B01AF, and B01AX.
- Utilization expressed as defined daily doses per 1000 inhabitants per day (DDD/TID); expenditure analysis conducted.
Main Results:
- National anticoagulant utilization increased from 14.15 to 27.67 DDD/TID between 2007 and 2017.
- DOAC utilization rose from 0.002 DDD/TID in 2008 to 6.04 DDD/TID in 2017, impacting warfarin use.
- In 2017, oral anticoagulants accounted for over half of expenditures (51.1%), with DOACs comprising 47.6% of this amount.
Conclusions:
- DOACs have shown significant growth in utilization and expenditure in the Czech Republic, largely at the expense of warfarin.
- The findings highlight a shift in anticoagulant prescribing patterns and associated costs.
- Further research on patient persistence and prescribing habits is recommended for a comprehensive understanding.
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