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An Efficient Method for the Isolation of Highly Purified RNA from Seeds for Use in Quantitative Transcriptome Analysis
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Accurate monitoring of sertraline (SRT) and N-desmethylsertraline (DSRT) levels is crucial for personalized depression treatment. This review details analytical methods for isolating and determining SRT and DSRT in biological samples for optimized patient care.

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Area of Science:

  • Pharmacology and Toxicology
  • Analytical Chemistry
  • Forensic Science

Background:

  • Sertraline (SRT) is a widely used selective serotonin reuptake inhibitor for depression.
  • Monitoring SRT and its metabolite N-desmethylsertraline (DSRT) is vital for personalized therapy and managing adverse reactions.
  • Accurate determination is needed in various biological matrices, including post-mortem samples.

Purpose of the Study:

  • To provide a comprehensive literature review of analytical methods for SRT and DSRT determination.
  • To critically assess extraction techniques and their optimization parameters.
  • To discuss the impact of detectors on the sensitivity of final determination methods.

Main Methods:

  • Review of extractive procedures: solid phase extraction, microextraction, and liquid-liquid extraction.
  • Analysis of extraction optimization parameters: pH, solvent type, and sorbent interactions.
  • Discussion of sample purification methods, including protein precipitation.
  • Overview of determination techniques: HPLC, LC, and GC with various detectors (UV, NPD, MS).

Main Results:

  • Extraction efficiency and precision vary significantly between different techniques.
  • Method optimization involves careful consideration of pH, solvent composition, and sorbent properties.
  • Mass spectrometry (MS) detectors offer superior sensitivity for SRT and DSRT quantification.

Conclusions:

  • A variety of sensitive and reliable analytical methods are available for SRT and DSRT determination.
  • Choosing the appropriate extraction and detection method is critical for accurate and precise quantification.
  • This review aids in selecting optimal methods for therapeutic drug monitoring and forensic analysis.