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Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
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An average sliding window correlation method for dynamic functional connectivity.

Victor M Vergara1, Anees Abrol1,2, Vince D Calhoun1,2

  • 1The Mind Research Network, Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico.

Human Brain Mapping
|January 20, 2019
PubMed
Summary
This summary is machine-generated.

Average sliding window correlation (ASWC) reduces artifacts and improves temporal resolution for analyzing brain connectivity dynamics. This new method offers a more accurate estimation of functional connectivity compared to standard sliding window correlation (SWC).

Keywords:
dynamic functional connectivityfunctional MRIsliding window correlation

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Area of Science:

  • Neuroscience
  • Signal Processing
  • Computational Biology

Background:

  • Sliding window correlation (SWC) is widely used for analyzing temporal brain connectivity.
  • SWC can produce spurious artifacts, particularly with large window lengths.
  • Recent recommendations suggest a 100s window for SWC, potentially sacrificing temporal resolution.

Purpose of the Study:

  • To introduce and evaluate a novel Average Sliding Window Correlation (ASWC) method.
  • To address the limitations of SWC, specifically artifact generation and temporal resolution.
  • To provide a more accurate estimation of transient functional connectivity dynamics.

Main Methods:

  • Development of the Average Sliding Window Correlation (ASWC) approach.
  • Utilizing simulated signals with controlled dynamic connectivity for testing.
  • Analytical modeling to explain ASWC and SWC behavior in different dynamic scenarios.
  • Application of ASWC to real neuroimaging data.

Main Results:

  • ASWC requires smaller window lengths, enhancing temporal resolution.
  • ASWC functions as a tunable high-pass filter.
  • ASWC demonstrates fewer artifacts and better detection of transient connectivity fluctuations than SWC.
  • ASWC achieves a lower mean square error compared to SWC.

Conclusions:

  • ASWC offers significant advantages over traditional SWC for brain connectivity analysis.
  • The ASWC method provides a more accurate and reliable assessment of dynamic functional connectivity.
  • ASWC is a promising technique for neuroimaging studies requiring high temporal resolution and artifact reduction.