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Effect of budesonide on pulmonary hyperinflation in young asthmatic children
A Greenough1, J Pool, J G Gleeson
1Paediatric Respiratory Laboratory, King's College Hospital, London.
Insights
Inhaled budesonide reduced lung hyperinflation in young children with asthma. This treatment also showed a trend toward improving bronchodilator response, suggesting benefits for pediatric asthma management.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Clinical Pharmacology
Background:
- Asthma is a common chronic respiratory disease in children.
- Hyperinflation, indicated by increased functional residual capacity (FRC), is a common finding in pediatric asthma.
- Effective management of childhood asthma requires addressing airway inflammation and airflow obstruction.
Purpose of the Study:
- To evaluate the effect of inhaled budesonide on functional residual capacity (FRC) in young asthmatic children.
- To assess the impact of budesonide treatment on bronchodilator responsiveness in this age group.
- To determine if inhaled corticosteroids can reduce lung hyperinflation in early childhood asthma.
Main Methods:
- A double-blind, randomized crossover trial was conducted.
- Nineteen children aged 2-6 years with asthma participated.
- Inhaled budesonide or placebo was administered for six weeks, with assessments of FRC (helium dilution) and bronchodilator response.
Main Results:
- Functional residual capacity (FRC) was elevated in most children at baseline.
- Budesonide treatment led to a significant reduction in FRC compared to placebo (median change 9% vs. 0%; p < 0.05).
- A trend towards improved bronchodilator response was observed after budesonide treatment.
Conclusions:
- Inhaled budesonide effectively reduces lung hyperinflation in young children with asthma.
- The findings suggest that inhaled corticosteroids are beneficial in managing hyperinflation in pediatric asthma.
- Budesonide may also positively influence bronchodilator responsiveness, warranting further investigation.
Abstract:
In 19 asthmatic children, aged 2-6 years, the effect of six weeks' treatment with inhaled budesonide or placebo on functional residual capacity (FRC--helium dilution) and bronchodilator responsiveness was assessed in a double blind, randomised crossover trial. FRC was increased in most children at the start of treatment. Treatment with budesonide was associated with a reduction in FRC by comparison with placebo (median change 9% v 0%; p less than 0.05). There was a trend towards a greater response to a bronchodilator after budesonide. The results suggest that inhaled corticosteroids reduce hyperinflation in young asthmatic children.