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Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
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Coding and decoding of oscillatory Ca2+ signals.

Benjamin Wacquier1, Valérie Voorsluijs2, Laurent Combettes3

  • 1Unit of Theoretical Chronobiology, Faculté des Sciences, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Seminars in Cell & Developmental Biology
|January 20, 2019
PubMed
Summary
This summary is machine-generated.

Calcium (Ca2+) oscillations are a universal signaling mechanism. This review explores how their frequency, irregularity, and interactions with other cellular components create versatile calcium signaling responses.

Keywords:
CalciumFrequency decodingIP(3) receptorsMitochondriaStochasticity

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Area of Science:

  • Cellular Biology
  • Biochemistry
  • Physiology

Background:

  • Calcium (Ca2+) oscillations, observed over 30 years ago, are now recognized as a fundamental mechanism of signal transduction.
  • These oscillations involve cyclical release and uptake of Ca2+ between the cytoplasm and endoplasmic reticulum, with frequency often correlating to stimulation levels.

Purpose of the Study:

  • To review the multifaceted nature of Ca2+ oscillations beyond their basic oscillatory mechanism.
  • To highlight how cellular context and interactions modulate Ca2+ signaling properties and physiological outcomes.
  • To discuss the exploitable irregularity inherent in Ca2+ oscillations.

Main Methods:

  • This is a review article, synthesizing existing research and evidence on Ca2+ signaling.
  • It analyzes the interplay between Ca2+ oscillations, inositol 1,4,5-trisphosphate metabolism, and various Ca2+ stores (e.g., extracellular medium, mitochondria).
  • The review discusses how these interactions fine-tune oscillatory characteristics and impact cellular responses.

Main Results:

  • The core Ca2+ oscillatory mechanism is extensively modulated by cell type and physiological conditions.
  • Interactions with other signaling pathways and Ca2+ stores significantly alter oscillation properties.
  • The intrinsic irregularity of Ca2+ oscillations is a feature that cells can utilize for signaling.

Conclusions:

  • Ca2+ signaling is highly versatile, with its properties finely tuned by various modulatory factors.
  • The complexity and irregularity of Ca2+ oscillations contribute to diverse and specific physiological responses.
  • Understanding these modulations is crucial for comprehending the full scope of Ca2+ signal transduction.