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Related Concept Videos

Somatic Spinal Reflexes01:22

Somatic Spinal Reflexes

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Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
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Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

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Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
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Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.7K
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
2.9K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Testes: Histology01:27

Testes: Histology

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A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
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Related Experiment Video

Updated: Jan 30, 2026

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer
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Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

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Somatic Testing: Implications for Targeted Treatment.

E Kate Reed, Linda Steinmark, Diane C Seibert

    Seminars in Oncology Nursing
    |January 21, 2019
    PubMed
    Summary
    This summary is machine-generated.

    Somatic genomic testing identifies cancer-driving variants for targeted treatments. Providers and patients must balance potential benefits against technological and logistical challenges for effective cancer care.

    Keywords:
    genomic testingprecision medicinesomatic testingtargeted treatment

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    Area of Science:

    • Oncology
    • Genomics
    • Cancer Treatment

    Background:

    • Genomic testing of cancer cells to identify specific variants is increasingly utilized in clinical practice.
    • This testing aims to detect genetic alterations that fuel cancer development and progression.

    Purpose of the Study:

    • To offer a comprehensive overview of critical factors involved in somatic testing for precision cancer therapy.
    • To highlight the importance of understanding the benefits and limitations of genomic variant identification in cancer treatment.

    Main Methods:

    • Review of existing literature and research reports.
    • Analysis of data sources pertaining to genomic testing in oncology.

    Main Results:

    • Somatic testing can identify numerous genomic variants.
    • These variants can guide the selection of targeted cancer therapies.

    Conclusions:

    • The widespread adoption of genomic testing necessitates careful consideration of its technological and logistical aspects by healthcare providers and patients.
    • Oncology nurses play a crucial role in patient-centered implementation, requiring a thorough understanding of testing's advantages and drawbacks.