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Modified Transverse-Vertical Gross Examination: a Better Method for the Detection of Definite Capsular Invasion in
Hye-Seon Oh1,2, Sun Jae Kim3, Eyun Song1
1Division of Endocrinology & Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Endocrine Pathology
|January 21, 2019
Summary
A modified gross examination method improves the detection of capsular invasion in encapsulated follicular-patterned thyroid carcinoma (EFPTC). This technique enhances differential diagnosis for thyroid nodules.
Area of Science:
- Pathology
- Surgical Pathology
- Thyroid Pathology
Background:
- Diagnosis of encapsulated follicular-patterned thyroid carcinoma (EFPTC) is challenging.
- Distinguishing benign from malignant thyroid lesions relies on detecting capsular and/or vascular invasion.
Purpose of the Study:
- To evaluate a modified transverse-vertical gross examination method for EFPTC diagnosis.
- To compare the efficacy of the modified method versus conventional methods in detecting invasion.
Main Methods:
- A modified transverse-vertical gross examination with additional vertical cuts was developed.
- Clinicopathological characteristics of EFPTC were compared between conventional and modified methods.
Main Results:
- The modified method significantly increased the diagnostic rates of follicular thyroid carcinoma and invasive encapsulated follicular variant of papillary thyroid carcinoma.
- Capsular invasion detection was significantly higher (OR=1.91) with the modified method.
- 23% of samples in the modified group showed invasion in the additional cuts.
Conclusions:
- The modified transverse-vertical gross examination method is more effective for detecting capsular invasion in EFPTC.
- This technique aids in the differential diagnosis of encapsulated micro-follicular proliferative thyroid lesions.
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