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Severe Cutaneous Adverse Reactions in Korean Pediatric Patients: A Study From the Korea SCAR Registry

Hea Lin Oh1, Dong Yoon Kang2,3, Hye Ryun Kang4,5

  • 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Allergy, Asthma & Immunology Research
|January 21, 2019
PubMed

Insights

Early clinical suspicion is key for managing severe cutaneous adverse drug reactions (SCARs) in children. This study analyzed pediatric SCAR cases, finding varied presentations but a low mortality rate, emphasizing proactive diagnosis and treatment.

Area of Science:

  • Pediatric Dermatology
  • Pharmacovigilance
  • Clinical Toxicology

Background:

  • Severe cutaneous adverse drug reactions (SCARs) are rare but serious, necessitating prompt diagnosis and treatment for better outcomes.
  • Limited data exists on the specific characteristics of SCARs in pediatric populations.

Purpose of the Study:

  • To investigate the clinical features, management strategies, and prognosis of SCARs in children.
  • To provide insights into the presentation and outcomes of pediatric SCARs.

Main Methods:

  • Retrospective analysis of pediatric SCAR cases from the Korean SCARs registry (2010-2015).
  • Inclusion of data from 34 tertiary referral university hospitals.
  • Descriptive analysis of etiology, clinical/laboratory findings, treatments, and prognosis.

Main Results:

  • Forty-seven pediatric SCAR cases were analyzed; males predominated (68.1%).
  • Antibiotics and antiepileptic drugs were the most frequent culprits.
  • Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Stevens-Johnson syndrome (SJS), and Toxic Epidermal Necrolysis (TEN) showed variable presentations and outcomes, with a 2.1% mortality rate.

Conclusions:

  • Pediatric SCARs, including DRESS, SJS, and TEN, exhibit diverse clinical presentations without a clear disease spectrum.
  • While mortality is low, clinical vigilance is crucial for effective management.
  • Proactive identification and treatment are paramount for improving pediatric SCAR prognoses.
Abstract

Keywords:
Drug eruptionsDrug-related side effects and adverse reactionschildren

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