Related Experiment Video

Updated: Aug 21, 2026

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Placental Epigenetic Alterations and IL-10 Dysregulation Drive Early Persistent Food Allergy

Eom Ji Choi1, Seung Hwa Lee2, Si Hyeon Lee2

  • 1Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Republic of Korea.

Allergy
|August 20, 2026
PubMed

Insights

Early persistent food allergy (FA) in children is linked to specific placental DNA methylation changes and altered cytokine profiles. These factors may drive the allergic inflammation and persistence observed in this food allergy trajectory.

Area of Science:

  • Immunology
  • Pediatrics
  • Epigenetics

Background:

  • Distinct food allergy (FA) trajectories in children lack clear underlying mechanisms.
  • Understanding these trajectories is crucial for targeted interventions.

Purpose of the Study:

  • Classify food allergy trajectories in children.
  • Investigate differences in placental DNA methylation and serum cytokine profiles across these trajectories.

Main Methods:

  • Utilized group-based trajectory modeling to classify 1518 children from the COCOA study into FA trajectories until age 7.
  • Measured serum cytokine levels at ages 3 and 7.
  • Performed placental DNA methylation profiling using Infinium MethylationEPIC BeadChip.

Main Results:

  • Identified four FA trajectories: no FA (87.3%), early remission (6.9%), early persistent (4.6%), and late remission (1.1%).
  • The early persistent FA group showed elevated IL-4, IL-5, and IL-6 levels at ages 3 and 7, and lower IL-10 at age 3.
  • Significant hypermethylation of RPS6KA2 and GCSAML genes was observed in the early persistent FA trajectory compared to others. GCSAML methylation correlated with IgE, eosinophils, and IL-5.

Conclusions:

  • Early persistent FA is associated with hypermethylation of RPS6KA2 and GCSAML.
  • Reduced IL-10 levels and elevated Th2 cytokines characterize the early persistent FA trajectory.
  • These epigenetic and cytokine alterations may contribute to allergic inflammation and persistence in early persistent food allergy.
Abstract

Keywords:
childcytokinefood hypersensitivitymethylationtrajectory

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