Related Experiment Video

Updated: Jan 30, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

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Advanced stage melanoma therapies: Detailing the present and exploring the future

Chelsea Luther1, Umang Swami2, Jun Zhang2

  • 1Department of Dermatology, Henry Ford Hospital, Detroit, MI, United States.

Critical Reviews in Oncology/Hematology
|January 22, 2019
PubMed

Insights

Recent advances offer numerous metastatic melanoma treatments, with combination therapies outperforming single drugs. This review details FDA-approved agents and emerging combination approaches for melanoma.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Metastatic melanoma treatment options were limited for decades, offering minimal survival benefits.
  • Significant advancements in melanoma therapies have occurred in the last ten years.
  • Diverse mechanisms of action characterize newly available treatment options.

Purpose of the Study:

  • To review United States Food and Drug Administration-approved melanoma treatment agents.
  • To outline therapies currently in clinical development for metastatic melanoma.
  • To focus on the efficacy and application of combination treatment approaches.

Main Methods:

  • Literature review of FDA-approved melanoma therapies.
  • Analysis of clinical trial data for emerging treatments.
  • Synthesis of information on combination regimens versus monotherapy.

Main Results:

  • Combination regimens have shown superiority over monotherapy, particularly with targeted agents.
  • Each therapeutic combination presents distinct advantages and side effect profiles.
  • A wide array of treatment options with varied mechanisms of action are now available.

Conclusions:

  • The landscape of metastatic melanoma treatment has dramatically evolved.
  • Combination therapies represent a superior strategy for managing metastatic melanoma.
  • Ongoing clinical development promises further advancements in melanoma treatment.
Keywords:
BRAFCTLA-4Combination therapyDabrafenibEpacadostatImmunotherapyIndoleamine 2,3-dioxygenaseIndoximod (D-1MT)IpilimumabMEDI4736Metastatic melanomaNivolumabPD1PembrolizumabTVECTalimogeneTargeted therapyVemurafenib

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