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Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

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Disseminated Strongyloidiasis.

Flávio Mileo Bacelar Guerreiro, Celso Tavares Sodré, Lorena Brandão Pavan

¹Professor Marcia Ramos-e-Silva, MD, PhD, Rua Dona Mariana 143 / C-32, Rio de Janeiro 22280-020, Brazil; ramos.e.silva@dermato.med.br.

Acta Dermatovenerologica Croatica : ADC

|January 23, 2019

Summary

This summary is machine-generated.

Strongyloidiasis, a parasitic infection, can disseminate in immunocompromised individuals, particularly those with Human T-lymphotropic virus type 1 (HTLV-1) coinfection. Cutaneous manifestations are key to diagnosing this severe disseminated form.

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Area of Science:

Infectious Diseases
Parasitology
Dermatology

Background:

Strongyloidiasis is a gastrointestinal parasitic infection caused by Strongyloides stercoralis, often asymptomatic.
Immunocompromised individuals are at risk for disseminated strongyloidiasis due to the parasite's opportunistic nature.
Coinfection with Human T-lymphotropic virus type 1 (HTLV-1) is a known risk factor for severe strongyloidiasis.

Observation:

A case study of a patient coinfected with HTLV-1 and Strongyloides stercoralis presenting with disseminated disease.
The patient exhibited purpuric reticulated periumbilical lesions and vibices on the flanks.
Histopathologic examination of skin lesions confirmed the presence of Strongyloides larvae in the deep reticular dermis.

Findings:

Disseminated strongyloidiasis can manifest with specific cutaneous findings.
The interaction between HTLV-1 and Strongyloides stercoralis can precipitate severe parasitic infections.
Skin lesions are crucial diagnostic indicators for disseminated strongyloidiasis.

Implications:

Increased awareness of the interplay between HTLV-1 and strongyloidiasis is vital for early diagnosis.
Recognition of cutaneous manifestations aids in identifying disseminated strongyloidiasis.
Prompt diagnosis and treatment are essential for managing severe forms of strongyloidiasis in at-risk populations.