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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Jan 30, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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360° ab-interno trabeculotomy in refractory primary open-angle glaucoma.

Steven R Sarkisian1, Basil Mathews2, Kai Ding2

  • 1University of Oklahoma College of Medicine, Dean McGee Eye Institute, Oklahoma City, OK, USA, steven-sarkisian@dmei.org.

Clinical Ophthalmology (Auckland, N.Z.)
|January 23, 2019
PubMed
Summary

Microinvasive glaucoma surgery (MIGS) using the TRAB360 device effectively lowered intraocular pressure (IOP) in patients with refractory primary open-angle glaucoma (POAG). This stand-alone procedure demonstrated a favorable safety profile over 12 months.

Keywords:
360 degree trabeculotomySchlemm’s canalTRAB360blebless MIGSglaucoma

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Area of Science:

  • Ophthalmology
  • Surgical Innovation
  • Glaucoma Management

Background:

  • Refractory primary open-angle glaucoma (POAG) presents a challenge in managing intraocular pressure (IOP).
  • Microinvasive glaucoma surgery (MIGS) offers less invasive alternatives for IOP reduction.

Purpose of the Study:

  • To assess the safety and efficacy of 360° ab-interno trabeculotomy with the TRAB360 device.
  • To evaluate the TRAB360 device as a stand-alone MIGS procedure for refractory POAG patients with preoperative IOP ≥18 mmHg.

Main Methods:

  • Retrospective analysis of 81 eyes undergoing stand-alone 360° ab-interno trabeculotomy using the TRAB360 device.
  • Effectiveness measured by IOP and medication reduction; safety assessed via adverse events and reinterventions.
  • Data collected at baseline and up to 12 months postoperatively; subgroup analysis for IOP ≥25 mmHg.

Main Results:

  • Statistically significant IOP reductions observed from 1 day to 12 months postoperatively.
  • At 12 months, mean IOP reduction was 7.3±6.7 mmHg; 59% achieved IOP <18 mmHg with reduced medication.
  • Subgroup (IOP ≥25 mmHg) showed 67% achieving target IOP and reduced medication; 25% required reintervention.

Conclusions:

  • Trabeculotomy with the TRAB360 device provides significant IOP reduction up to 1 year.
  • The procedure exhibits a favorable safety profile.
  • TRAB360 is an effective stand-alone MIGS option for refractory POAG.