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Updated: Jan 30, 2026

Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
Atypical Cowpox Virus Infection in Smallpox-Vaccinated Patient, France
Abstract:
We report a case of atypical cowpox virus infection in France in 2016. The patient sought care for thoracic lesions after injury from the sharp end of a metallic guardrail previously stored in the ground. We isolated a cowpox virus from the lesions and sequenced its whole genome. The patient reported that he had been previously vaccinated against smallpox. We describe an alternative route of cowpox virus infection and raise questions about the immunological status of smallpox-vaccinated patients for circulating orthopoxviruses.
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