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Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis
Published on: December 16, 2013
The roles of Lewis acidic additives in organotransition metal catalysis
Joseph Becica1, Graham E Dobereiner1
1Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA. dob@temple.edu.
Abstract:
We describe recent examples of prominent reactions in organic synthesis that involve transition metal and Lewis acid cocatalysts. Introducing Lewis acid additives to transition metal catalysis can enable new reactivity or improve activity and selectivity of an existing process. Several studies are highlighted to illustrate the possible roles of Lewis acids in catalytic mechanisms. The uses of Lewis acid additives in bond-breaking catalysis (C-C activation, C-H activation, and hydrogenolysis reactions) and bond-forming catalysis (Au-catalysed alkyne functionalisation, Pd-catalysed C-C and C-N bond formation) are reviewed.
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