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[Consumption of antibiotics in a burns intensive care unit]

Björn Steinke1, Armin Sablotzki1, Thomas Kremer2

  • 1Klinikum St. Georg - Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie.

Handchirurgie, Mikrochirurgie, Plastische Chirurgie : Organ Der Deutschsprachigen Arbeitsgemeinschaft Fur Handchirurgie : Organ Der Deutschsprachigen Arbeitsgemeinschaft Fur Mikrochirurgie Der Peripheren Nerven Und Gefasse : Organ Der V
|January 23, 2019
PubMed

Insights

Severe burn patients in Germany do not require more antibiotics than other surgical intensive care patients. Antibiotic use patterns in burn care reflect specific pathogen profiles, with Staphylococcus aureus and Enterococcus faecalis being most common.

Area of Science:

  • Intensive Care Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Burn-injured patients face a high risk of infection, suggesting increased antibiotic needs compared to general ICU patients.
  • Limited data exists on antibiotic consumption specifically for severe burn patients in Germany.
  • This study aimed to quantify antibiotic use in severe burn patients and compare it to surgical ICUs.

Purpose of the Study:

  • To determine the antibiotic consumption in severe burn patients.
  • To compare antibiotic consumption in severe burn patients with that in surgical intensive care units.
  • To identify patterns in antibiotic use and associated pathogens in burn care.

Main Methods:

  • Retrospective analysis of 136 severe burn patients treated between 2013 and 2016 in a regional burn center's ICU.
  • Antibiotic usage recorded via electronic medical records.
  • Calculated antibiotic consumption using Recommended Daily Doses (RDD) and Defined Daily Doses (DDD) per patient days.

Main Results:

  • Antibiotic therapy was administered to 60.3% of patients.
  • Total antibiotic consumption was 77.38 RDD/100 PT or 937.64 DDD/1000 PT, slightly lower than surgical ICUs.
  • Most frequent antibiotics included fluoroquinolones, carbapenems, and aminopenicillins/BLI.
  • Common pathogens were Staphylococcus aureus (54.4%), Enterococcus faecalis (54.4%), E. coli (37.5%), and Pseudomonas aeruginosa (36.8%).

Conclusions:

  • Antibiotic consumption in severe burn patients is comparable to other surgical ICU patients.
  • Specific antibiotic classes used reflect the unique spectrum of pathogens encountered in burn populations.
  • Findings highlight the need for tailored antibiotic strategies in burn care based on prevalent microorganisms.
Abstract

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