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Behaviour of Tetrabenazine in Acid Medium: Reassessment and Impact on Formulation

Laurent Ettouati1, Zoé Senta-Loys2, Sandrine Bourgeois3,4

  • 1EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453-INSERM US7, Faculté de Pharmacie⁻ISPB, Université Claude Bernard Lyon, Université de Lyon, 18 avenue Rockefeller, F-69373, Lyon Cedex 8, France. laurent.ettouati@univ-lyon1.fr.

Pharmaceutics
|January 24, 2019
PubMed

Keywords:
LC-MSacid mediumdegradation impuritiesdeuterated tetrabenazinedeuterationorodispersible filmstabilitysynthesistetrabenazine

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