Escherichia hermannii Infections in Humans: A Systematic Review

Eshcerichia hermannii is a member of the Enterobacteriaceae, first described in 1982 and reclassified as a distinct species in the Escherichia genus after identifying biochemical and genomic differences from E. coli. It is a rare cause of human infections and is supposed to be a co-infector rather than an autonomous cause of infection. The aim of this systematic review was to record and evaluate all available evidence regarding human infections by E. hermannii. A systematic review of PubMed (through 21 December 2018) for studies providing epidemiological, clinical, and microbiological information, as well as treatment data and outcomes of E. hermannii infections was performed. A total of 16 studies, containing data of 17 patients, were eventually included in the analysis. The most common E. hermannii infections were bacteremias, urinary tract, and central nervous system infections. The complication rate, like the occurrence of sepsis, was high. Cephalosporins and aminoglycosides were the most common agents used for treatment. This systematic review describes bacterial infections by E. hermannii and provides information on the epidemiology, clinical presentation, antibiotic resistance, treatment, and outcomes associated with these infections.