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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
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Gender Differences and Obesity Influence on Pulmonary Function Parameters.

Rahimah Zakaria1, Noraini Harif1, Badriya Al-Rahbi2

  • 1Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Oman Medical Journal
|January 24, 2019
PubMed
Summary
This summary is machine-generated.

Males have higher pulmonary function test (PFT) values than females. Increased body mass index (BMI) may indicate restrictive lung patterns in patients undergoing PFT.

Keywords:
Body Mass IndexGenderPulmonary Function Test

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Area of Science:

  • Pulmonary Medicine
  • Obesity Research
  • Clinical Physiology

Background:

  • Overweight and obesity are linked to altered pulmonary function test (PFT) parameters.
  • Understanding gender-specific PFT changes and BMI correlations is crucial for accurate diagnosis.

Purpose of the Study:

  • To investigate gender differences in PFT parameters.
  • To examine the relationship between body mass index (BMI) and PFT parameters.

Main Methods:

  • Retrospective analysis of 126 patients referred for PFT.
  • PFT measurements using spirometry.
  • Body Mass Index (BMI) calculated using Quetelet's index.

Main Results:

  • Females showed lower mean PFT values than males.
  • Forced Vital Capacity (FVC)% predicted was <80% in all patients.
  • Increased BMI correlated positively with peak expiratory flow and FEV1/FVC ratio in males.

Conclusions:

  • Males generally exhibit higher PFT parameter values than females.
  • Elevated BMI may suggest a restrictive spirometry pattern.
  • Further research into BMI's impact on PFT across genders is warranted.