Related Experiment Video

Updated: Jan 30, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
05:06

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

12.8K

The efficacy and safety of lenvatinib for advanced hepatocellular carcinoma in a real-world setting

Shuntaro Obi1,2,3, Takahisa Sato4, Shinpei Sato4,5

  • 1Internal Medicine, Chiba General Medical Center, Teikyo University, 3426-3 Anesaki, Ichihara, 299-0111, Chiba, Japan. obis@med.teikyo-u.ac.jp.

Hepatology International
|January 24, 2019
PubMed
Abstract

Insights

Lenvatinib demonstrated good response and safety in advanced hepatocellular carcinoma patients in a real-world setting. Adverse events were manageable with dose adjustments, showing lenvatinib

Area of Science:

  • Hepatocellular Carcinoma Research
  • Oncology Drug Efficacy
  • Real-World Evidence Studies

Background:

  • Lenvatinib, a multi-targeted tyrosine kinase inhibitor, showed non-inferiority to sorafenib in advanced hepatocellular carcinoma (HCC) during the REFLECT trial.
  • Real-world data is crucial for understanding treatment outcomes beyond controlled clinical trials.

Purpose of the Study:

  • To evaluate the efficacy and safety of lenvatinib in a real-world patient population with advanced HCC.
  • To assess treatment response and adverse event profiles in routine clinical practice.

Main Methods:

  • A retrospective, multicenter, observational study design.
  • Inclusion/exclusion criteria mirrored the REFLECT trial.
  • Patients received lenvatinib (8 or 12 mg/day) with observation for at least 12 weeks; response assessed by m-RECIST at week 8.

Main Results:

  • The study included 16 patients with prior treatment history, a median of 3.9 years post-initial treatment.
  • Most frequent adverse events (AEs) included fatigue, hypertension, and proteinuria, often exceeding Grade 2 but manageable.
  • Objective response rate was 40% (6 partial responses, 8 stable disease).

Conclusions:

  • Lenvatinib treatment is feasible and effective in a real-world setting for advanced HCC.
  • Manageable adverse events and a notable objective response rate support lenvatinib's utility.
Keywords:
Clinical practiceEfficacyHepatocellular carcinomaLenvatinib

More Related Videos

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice10:35

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Published on: September 25, 2013

37.2K
Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients05:31

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

6.2K

Related Concept Videos

Survey Safety01:28

Survey Safety

Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
390
Self-Efficacy01:29

Self-Efficacy

Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
224
Household Wiring And Electrical Safety01:13

Household Wiring And Electrical Safety

Companies that supply power to most modern households use three conductors, typically called a three-wire line. While one is neutral, the other two are both at 120 V but with opposite polarity, giving a voltage of 240 V between them. With a three-wire line, high-power appliances that require 240 V, such as electric stoves and clothes dryers, are linked between the two hot lines. 120 V appliances can be connected between the neutral and either of the hot lines. The neutral side, which is always...
1.7K
Setting Time of Cement01:12

Setting Time of Cement

The setting time of cement refers to the process of cement paste transitioning from a plastic state to a solid state. This process is crucial in construction as it dictates the timeframe for concrete placement, compaction, and finishing. The onset of this solidification is termed the initial set, indicating when the paste becomes unworkable. The final set is when the paste has solidified completely, and further handling or manipulation can no longer affect its shape. The cement strength is...
664
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups


Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.8K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.1K