Related Experiment Video
Updated: Jan 30, 2026
11:27
Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
17.2K
Clear Cell Papillary Renal Cell Carcinoma.
Jianping Zhao1, Eduardo Eyzaguirre1
1From the Department of Pathology, University of Texas Medical Branch, Galveston.
Archives of Pathology & Laboratory Medicine
|January 24, 2019
Summary
Clear cell papillary renal cell carcinoma (ccpRCC) is a distinct kidney cancer variant. Accurate diagnosis requires distinguishing it from other clear cell renal cell carcinoma (RCC) types using specific features and immunohistochemistry.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- Clear cell papillary renal cell carcinoma (ccpRCC) is an emerging entity in renal cell carcinoma (RCC) classification.
- It presents unique morphological and immunohistochemical characteristics.
- ccpRCC exhibits an indolent clinical behavior compared to other RCC subtypes.
Purpose of the Study:
- To review the clinical, gross, and histopathologic features of ccpRCC.
- To discuss the utility of immunohistochemistry and genetic profiling in diagnosing ccpRCC.
- To outline the prognosis associated with ccpRCC.
Main Methods:
- Review of existing literature on ccpRCC.
- Analysis of histopathologic features.
- Evaluation of immunohistochemical and genetic data.
Main Results:
- ccpRCC can be mistaken for other clear cell or papillary RCC variants.
- Immunohistochemistry is crucial for differentiating ccpRCC in ambiguous cases.
- ccpRCC has a generally favorable prognosis.
Conclusions:
- Accurate identification of ccpRCC is essential due to its distinct nature and behavior.
- A high index of suspicion and appropriate diagnostic tools are necessary.
- Understanding ccpRCC features aids in patient management and prognosis assessment.
More Related Videos
05:36Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
Published on: February 8, 2020
9.5K
06:38A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
14.2K
Related Concept Videos
01:11Papillary Dermis
5.6K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.6K
01:17Factors Affecting Renal Clearance: Renal Impairment
460
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
460
01:20Renal Corpuscle
7.4K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
7.4K
01:23Renal Clearance
2.7K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
2.7K
01:08Renal Drug Clearance: Comparison Between Renal Excretion Methods
608
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
608
01:07What are Cells?
199.2K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
199.2K