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Updated: Jan 30, 2026
06:47
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
10.2K
Current and emerging biologic and small molecule therapies for atopic dermatitis
Randall Li1,2,3, Suhail Hadi1, Emma Guttman-Yassky1,2
1a Department of Dermatology, Laboratory of Inflammatory Skin Diseases , Icahn School of Medicine at Mount Sinai , New York , NY , USA.
Expert Opinion on Biological Therapy
|January 24, 2019
Summary
New therapies offer hope for managing atopic dermatitis (AD). Understanding AD pathogenesis has led to targeted treatments for this common inflammatory skin disease, promising safer long-term control.
Area of Science:
- Dermatology and immunology, focusing on inflammatory skin diseases.
Background:
- Atopic dermatitis (AD) is a prevalent inflammatory skin condition with limited safe, long-term systemic therapies for adults until recently.
- Advances in understanding AD pathogenesis have revealed molecular and cellular drivers, leading to a new wave of therapeutic development.
Purpose of the Study:
- To review the emerging landscape of biologic and small molecule antagonists for atopic dermatitis management.
- To discuss therapies targeting key immune pathways implicated in AD, including Th2, Th22, Th17/IL-23, and JAK-STAT.
- To explore the link between pruritus and various therapeutic approaches in AD.
Main Methods:
- Review of current literature on AD pathogenesis and therapeutic pipelines.
- Analysis of immune axes and molecular targets in AD.
- Discussion of phenotypic variations and personalized medicine approaches.
Main Results:
- A growing number of targeted therapies are available for AD, addressing multiple immune pathways.
- Therapies are emerging to manage pruritus, a significant symptom of AD.
- Recognition of diverse AD phenotypes necessitates tailored treatment strategies.
Conclusions:
- The evolving understanding of AD pathogenesis has spurred the development of novel, targeted therapies.
- Personalized medicine approaches, considering specific AD phenotypes and immune traits, are crucial for future pharmacotherapy.
- New treatments hold promise for safer and more effective long-term management of atopic dermatitis.
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