Related Experiment Video

Updated: Aug 5, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Achieving Minimal Disease Activity in Atopic Dermatitis Is Associated with Fewer Flares, Reduced Healthcare Resource

Jonathan I Silverberg¹, Vimal H Prajapati^2,3,4,5, Susanne Abraham⁶

¹Department of Dermatology, George Washington University School of Medicine and Health Sciences, Suite 2B-425, 2150 Pennsylvania Avenue NW, Washington, DC, 20037, USA. jonathanisilverberg@gmail.com.

Dermatology and Therapy

|July 30, 2026

Abstract

Introduction:

Atopic dermatitis (AD), a chronic inflammatory condition, is the leading cause of global burden from skin disease. Optimal targets for clinician-reported outcomes (ClinROs) and patient-reported outcomes (PROs), including minimal disease activity (MDA; defined as simultaneous achievement of ≥ 1 optimal ClinRO and ≥ 1 optimal PRO), were established following the Aiming High in Eczema/Atopic Dermatitis (AHEAD) initiative. This study evaluated the impact of MDA achievement on flare activity, healthcare resource utilization, and patient-reported disease control in adults with moderate-to-severe AD.

Methods:

This retrospective post hoc analysis used data from the real-world cross-sectional MEASURE-AD study and included adults with moderate-to-severe AD across 28 countries. Three definitions were used to identify achievement of MDA. Outcomes were measured using patient-reported questionnaires evaluating flare activity and healthcare resource utilization over the preceding 6 months, as well as patient-reported disease control assessed at the time of the questionnaire. Statistical analyses compared patients achieving MDA targets with non-MDA groups using Kruskal-Wallis tests.

Results:

Patients achieving MDA experienced fewer flares (means ranging from 0.8 to 1.4) compared with non-MDA groups (3.8-9.8) over the preceding 6 months. Flares were shorter in duration, with 9.9-13.4% of patients who achieved MDA reporting flares longer than 7 days compared with 26.4-51.1% of patients across non-MDA groups. Patients who met neither optimal ClinRO or PRO reported a 2.2- to 2.7-fold increase in average number of healthcare visits compared with MDA groups. More patients who achieved MDA indicated complete agreement that their AD was effectively controlled (86.7-94.2%) compared with those who did not achieve MDA (19.2-74.1%).

Conclusions:

Achievement of MDA in patients with moderate-to-severe AD was associated with less frequency and duration of flares, reduced healthcare resource utilization, and increased patient-reported disease control compared with those who did not achieve MDA. These findings emphasize the importance of holistic assessments when evaluating treatment outcomes in AD.

Trial Registration:

ClinicalTrials.gov Identifiers NCT03569293 (Measure Up 1), NCT03607422 (Measure Up 2), and NCT03568318 (AD Up).

Keywords:

Atopic dermatitis Inflammation Itch JAK Janus kinase inhibitors Skin barrier dysfunction

Related Concept Videos

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Acne Infection

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

Inflammatory Bowel Disease IV: Pharmacological Management

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...

Articles linked to this work by shared authors, journal, and citation graph.

Current research landscape and future prospects of in silico modeling approaches for atopic dermatitis.

JID innovations : skin science from molecules to population health·2026

Growth Assessment in Children Under 12 Years With Moderate-to-Severe Atopic Dermatitis Included in the PEDISTAD Observational Registry.

Pediatric dermatology·2026

Optimising enteral feeding prevents postnatal growth faltering in preterm infants: a retrospective cohort study.

BMJ nutrition, prevention & health·2026

Healthcare resource use, costs and health-related quality of life in the UK-Irish Atopic eczema Systemic Therapy Register (A-STAR): a pilot study.

Skin health and disease·2026

Dupilumab treatment improves linear growth and bone biomarkers in children with atopic dermatitis: Post hoc analysis of a phase 3 randomized, placebo-controlled clinical trial and an open-label extension study.

Journal of the American Academy of Dermatology·2026

Three-Year Efficacy and Safety of Lebrikizumab in Patients with Moderate-to-Severe Atopic Dermatitis: A Long-Term Extension (ADjoin).

Dermatology and therapy·2026

See all related articles