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Related Concept Videos

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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From DNA to Protein03:06

From DNA to Protein

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The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
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Recombinant DNA

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Overview
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DNA Replication02:40

DNA Replication

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DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
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DNA-only Transposons02:57

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DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
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Translesion DNA Polymerases02:10

Translesion DNA Polymerases

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Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
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[An update on DNA sequencing].

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Illumina's acquisition of Pacific Biosciences may reshape DNA sequencing. This update examines the dynamic field and potential technological disruptions.

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Area of Science:

  • Genomics
  • Biotechnology
  • Molecular Biology

Background:

  • The DNA sequencing industry is dynamic with multiple key players.
  • Technological innovation continues to drive advancements in the field.
  • The competitive landscape is subject to significant shifts.

Purpose of the Study:

  • To provide an update on the current state of the DNA sequencing field.
  • To analyze the potential impact of major industry acquisitions.
  • To highlight emerging technologies that could disrupt the market.

Main Methods:

  • Review of current literature and industry reports.
  • Analysis of market trends and competitive dynamics.
  • Assessment of technological advancements in DNA sequencing.

Main Results:

  • The planned acquisition of Pacific Biosciences by Illumina is a significant event.
  • Several innovative technologies are poised to impact the DNA sequencing market.
  • The field remains open to disruption by new entrants and novel approaches.

Conclusions:

  • The acquisition could lead to a consolidation of power in the DNA sequencing market.
  • Continued innovation is expected to drive competition and technological progress.
  • The future of DNA sequencing will likely be shaped by both M&A activity and technological breakthroughs.