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Updated: Aug 19, 2026

Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits
Published on: March 16, 2016
Rapamycin and Alzheimer's disease: Time for a clinical trial?
Matt Kaeberlein1, Veronica Galvan2,3
1Department of Pathology, University of Washington, Seattle, WA 98045, USA. kaeber@uw.edu galvanv@uthscsa.edu.
Abstract:
The drug rapamycin has beneficial effects in a number of animal models of neurodegeneration and aging including mouse models of Alzheimer's disease. Despite its compelling preclinical record, no clinical trials have tested rapamycin or other mTOR inhibitors in patients with Alzheimer's disease. We argue that such clinical trials should be undertaken.
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