Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

4.2K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
4.2K
Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

9.3K
Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
9.3K
COP Coated Vesicles00:59

COP Coated Vesicles

18.2K
Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
18.2K
Coat Assembly and GTPases01:33

Coat Assembly and GTPases

4.4K
Vesicles incorporate different coat protein subunits in different cell locations, which changes the properties of the coat, such as the shape and geometry of the transport vesicles. Thus, vesicle coat proteins also play a significant role in cargo selection.
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...
4.4K
Body Temperature01:25

Body Temperature

4.3K
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
4.3K
Body Temperature01:07

Body Temperature

1.4K
Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trimethylamine-producing microbe Bacillus megaterium KCTC 3007 promotes antitumor immunity in endometrial cancer via type I interferon response pathways.

Microbiome·2026
Same author

Emergence of magnetic monopole-like behavior in iron oxide nanoparticles grafted with chiral brushes: a chiral induced spin selectivity manifestation.

Materials horizons·2026
Same author

Interplay Between Exfoliation and Functionalization Strategies for Group VI Layered Transition Metal Dichalcogenide Dispersions.

Nanomaterials (Basel, Switzerland)·2026
Same author

Simulation-guided design of peptide-metal coordination interfaces for next-generation metallo-immunotherapy.

Nano convergence·2026
Same author

<i>Lactobacillus delbrueckii</i> subsp. <i>lactis</i> CKDB001 Ameliorates Scopolamine-Induced Cognitive Impairment Through Metabolic Modulation.

International journal of molecular sciences·2025
Same author

Functional Expansion of the Skin Microbiome: A Pantothenate-Producing <i>Rothia</i> Strain Confers Anti-Inflammatory and Photoaging-Protective Effects.

International journal of molecular sciences·2025
Same journal

Investigating Nonlinear Fatigue Damage Evolution of SBS-Modified Asphalt Mixtures with Physical Gel Structure.

Gels (Basel, Switzerland)·2026
Same journal

Nano-Iron (III) Oxide-Doped Poly (Itaconic Acid-Co-Acrylamide)/Sodium Alginate Hydrogel for Saline-Alkali Soil Amelioration and Wheat Growth.

Gels (Basel, Switzerland)·2026
Same journal

Evaluation of Starch-Derived Hydrogel Systems for Artifact-Cleaning Applications.

Gels (Basel, Switzerland)·2026
Same journal

Bioorthogonally Cross-Linked Injectable PEG Hydrogel with Robust Hemostatic and Antibacterial Properties.

Gels (Basel, Switzerland)·2026
Same journal

Robust Polyurethane Hydrogels Based on Dynamic Disulfide Bonds and Pendant Tertiary Amines with Room-Temperature Self-Healing and pH Responsiveness.

Gels (Basel, Switzerland)·2026
Same journal

An Environmentally Tolerant 5A Hydrogel with Photothermal Effect for Frostbite Treatment.

Gels (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Jan 30, 2026

Fabrication of Periodic Gold Nanocup Arrays Using Colloidal Lithography
08:21

Fabrication of Periodic Gold Nanocup Arrays Using Colloidal Lithography

Published on: September 2, 2017

7.6K

Temperature-Responsive Hydrogel-Coated Gold Nanoshells.

Hye Hun Park1, La-Ongnuan Srisombat2, Andrew C Jamison3

  • 1Department of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, TX 77204-5003, USA. hhpark95@gmail.com.

Gels (Basel, Switzerland)
|January 25, 2019
PubMed
Summary
This summary is machine-generated.

Researchers developed temperature-responsive gold nanoshells for photothermal drug delivery. These nanoparticles, coated with poly(N-isopropylacrylamide-co-acrylic acid), show a temperature-dependent size change and optimal optical properties for biomedical use.

Keywords:
drug deliverygold nanoshellhydrogel coatingtemperature responsive

More Related Videos

Growth of Gold Dendritic Nanoforests on Titanium Nitride-coated Silicon Substrates
05:02

Growth of Gold Dendritic Nanoforests on Titanium Nitride-coated Silicon Substrates

Published on: June 3, 2019

6.9K
Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots
05:43

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots

Published on: January 13, 2023

4.3K

Related Experiment Videos

Last Updated: Jan 30, 2026

Fabrication of Periodic Gold Nanocup Arrays Using Colloidal Lithography
08:21

Fabrication of Periodic Gold Nanocup Arrays Using Colloidal Lithography

Published on: September 2, 2017

7.6K
Growth of Gold Dendritic Nanoforests on Titanium Nitride-coated Silicon Substrates
05:02

Growth of Gold Dendritic Nanoforests on Titanium Nitride-coated Silicon Substrates

Published on: June 3, 2019

6.9K
Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots
05:43

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots

Published on: January 13, 2023

4.3K

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Gold nanoshells offer unique optical properties for photothermal applications.
  • Temperature-responsive polymers can create smart drug delivery systems.
  • Developing targeted drug delivery systems is crucial for effective therapies.

Purpose of the Study:

  • To create a photothermally-induced drug-delivery system using gold nanoshells.
  • To encapsulate gold nanoshells within a temperature-responsive polymer shell.
  • To characterize the properties and potential biomedical applications of the composite nanoparticles.

Main Methods:

  • Synthesized gold nanoshells (~160 nm) encapsulated in poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)).
  • Utilized scanning electron microscopy (SEM) for morphology analysis.
  • Employed dynamic light scattering (DLS) to characterize temperature-responsive behavior.
  • Investigated optical properties using UV-visible spectroscopy.
  • Conjugated avidin to the nanoparticle surface for biotin-4-fluorescein (biotin-4-FITC) modification.

Main Results:

  • The P(NIPAM-co-AA) shell exhibited temperature-responsive behavior, decreasing in diameter with increasing temperature.
  • The composite nanoshells displayed a surface plasmon resonance (SPR) peak at ~800 nm, suitable for biomedical applications.
  • Successful conjugation of avidin and biotin-4-FITC was achieved for imaging purposes.

Conclusions:

  • The developed hydrogel-coated gold nanoshells are promising for photothermally-controlled drug delivery.
  • The temperature-responsive polymer shell enables tunable drug release.
  • The optical properties and surface modification facilitate biomedical applications and monitoring.