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Comparison of Oxidative Effects of Two Different Administration Form of Oxybutynin in the Potential Target Tissues

Kaan Kaltalioglu1, Fatmanur Tugcu-Demiroz2, Fusun Acarturk2

  • 1Espiye Vocational School, Giresun University, 28600 Giresun, Turkey.

Advances in Urology
|January 25, 2019
PubMed

Insights

Vaginal oxybutynin delivery may reduce oxidative stress and side effects compared to oral administration for overactive bladder. This study compared oral versus vaginal oxybutynin effects on oxidative parameters in rabbits.

Area of Science:

  • Pharmacology
  • Urology
  • Toxicology

Background:

  • Oxybutynin, an anticholinergic, treats overactive bladder (OAB) but causes side effects.
  • New drug delivery methods are sought to mitigate oxybutynin's adverse effects.
  • Vaginal delivery is explored as an alternative route for oxybutynin administration.

Purpose of the Study:

  • To compare the effects of oral versus vaginal oxybutynin delivery on oxidative stress parameters.
  • To investigate tissue-specific changes in nitric oxide (NOx), TBARs, and glutathione (GSH) levels.

Main Methods:

  • Female New Zealand white rabbits (n=12) were divided into oral and vaginal oxybutynin delivery groups.
  • Animals were sacrificed 48 hours post-administration.
  • Spectrophotometric analysis of NOx, TBARs, and GSH levels in aorta, salivary gland, and small intestine tissues.

Main Results:

  • Vaginal delivery significantly reduced NOx levels in all tested tissues compared to oral delivery (p < 0.05).
  • Vaginal administration also decreased TBARs levels in salivary gland and aorta tissues (p < 0.05).
  • No significant differences in GSH levels were reported between the groups.

Conclusions:

  • Vaginal oxybutynin delivery demonstrates a potential to mitigate oxidative stress.
  • This route may reduce the incidence of oxidant-induced side effects associated with oral oxybutynin.
  • Further research into vaginal oxybutynin delivery for OAB management is warranted.

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