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Updated: Jan 30, 2026

Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions
Published on: July 3, 2025
Poly(allylamine hydrochloride)-functionalized reduced graphene oxide for synergistic chemo-photothermal therapy
Shounak Roy1, Ankita Sarkar1, Amit Jaiswal1
1School of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Mandi-175005, Himachal Pradesh, India.
Aim:
To develop near-infrared (NIR) light-responsive reduced graphene oxide (RGO)-based nanocomposites with improved stability, biocompatibility and enhanced in vitro chemo-photothermal therapeutic efficiency.
Materials & Methods:
Poly(allylamine hydrochloride)-functionalized RGO-based nanocomposites (RGO-PAH) were synthesized and thoroughly characterized. In vitro biocompatibility, cellular uptake and in vitro synergistic chemo-photothermal therapeutic efficiency of drug-loaded RGO-PAH nanocomposites were evaluated along with elucidation of cell death mechanism.
Results:
RGO-PAH nanocomposites showed excellent photothermal transduction, pH-dependent drug release, rapid internalization, high biocompatibility and highly efficient synergistic in vitro chemo-photothermal therapy via apoptosis induction through increase in intracellular reactive oxygen species (ROS) production followed by oxidative DNA damage.
Conclusion:
Excellent biocompatibility and highly efficient chemo-photothermal killing of cancer cells at a very low concentration reflects the potential of RGO-PAH as a NIR-responsive therapeutic agent for cancer therapy.
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