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Emerging and Reemerging Aedes-Transmitted Arbovirus Infections in the Region of the Americas: Implications for Health
Marcos A Espinal1, Jon K Andrus1, Barbara Jauregui1
1Marcos A. Espinal is with Communicable Diseases and Environmental Determinants of Health, Pan American Health Organization/World Health Organization, Washington, DC. Jon K. Andrus is with the Department of Global Health, George Washington University Milken Institute of Public Health, Washington, DC, and the Division of Vaccines and Immunization, Center for Global Health, University of Colorado, Boulder. Barbara Jauregui is with the Department of Global Health, Milken Institute of Public Health, George Washington University. Stephen Hull Waterman is with the Dengue Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico. David Michael Morens is with the Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. Jose Ignacio Santos is with the Experimental Medicine Research Unit, Medical School, National Autonomous University of Mexico, Mexico City, Mexico. Olaf Horstick is with the Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany. Lorraine Ayana Francis is with Communicable Diseases & Emergency Response, Caribbean Public Health Agency, Port-of-Spain, Trinidad. Daniel Olson is with the Pediatric Infectious Disease Department, University of Colorado School of Medicine, and Epidemiology Department, Colorado School of Public Health, Aurora.
Abstract:
The increasing geographical spread and disease incidence of arboviral infections are among the greatest public health concerns in the Americas. The region has observed an increasing trend in dengue incidence in the last decades, evolving from low to hyperendemicity. Yellow fever incidence has also intensified in this period, expanding from sylvatic-restricted activity to urban outbreaks. Chikungunya started spreading pandemically in 2005 at an unprecedented pace, reaching the Americas in 2013. The following year, Zika also emerged in the region with an explosive outbreak, carrying devastating congenital abnormalities and neurologic disorders and becoming one of the greatest global health crises in years. The inadequate arbovirus surveillance in the region and the lack of serologic tests to differentiate among viruses poses substantial challenges. The evidence for vector control interventions remains weak. Clinical management remains the mainstay of arboviral disease control. Currently, only yellow fever and dengue vaccines are licensed in the Americas, with several candidate vaccines in clinical trials. The Global Arbovirus Group of Experts provides in this article an overview of progress, challenges, and recommendations on arboviral prevention and control for countries of the Americas.
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