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Updated: Jan 30, 2026
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Immune responses to zoster vaccines
Myron J Levin1,2, Adriana Weinberg1,2,3
1a Departments of Pediatrics , University of Colorado Denver School of Medicine, Anschutz Medical Campus , Aurora , CO , USA.
The recombinant zoster vaccine (RZV) shows superior efficacy and longer-lasting protection compared to the live zoster vaccine (ZVL). Immunologic responses also favor RZV, supporting its enhanced effectiveness in preventing shingles.
Area of Science:
- Immunology
- Vaccinology
- Virology
Background:
- Two herpes zoster vaccines are available: a live attenuated varicella-zoster virus (VZV) vaccine (ZVL) and a recombinant zoster vaccine (RZV).
- RZV utilizes VZV glycoprotein E (gE) combined with the AS01B adjuvant system.
Purpose of the Study:
- To compare the efficacy and immunologic responses of the recombinant zoster vaccine (RZV) versus the live zoster vaccine (ZVL).
Main Methods:
- Comparative analysis of vaccine efficacy and duration of protection.
- Immunologic studies assessing T cell responses (peak memory, persistence, polyfunctionality).
Main Results:
- RZV demonstrates superior efficacy compared to ZVL.
- RZV's protective effect is not diminished by age and shows minimal waning over 4 years.
- RZV recipients exhibit higher peak and persistent T cell responses, including polyfunctional T cells, compared to ZVL recipients.
Conclusions:
- Immunologic data support the superior and sustained efficacy of RZV over ZVL for herpes zoster prevention.
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