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Polymers02:34

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Polymer Classification: Architecture01:14

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Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
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Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
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Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
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Unlike small molecules with definite molecular weights, polymers are a mixture of individual polymer chains of varying lengths, each with a unique molecular weight.  So, the molecular weight of a polymer is expressed as an average value based on the average size of the polymer chains. The two most common forms of averages used for polymers are the number average molecular weight and weight average molecular weight.
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Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
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Protein-Polymer Dynamics as Affected by Polymer Coating and Interactions.

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Polymer coatings on proteins influence their flexibility and dynamics. Even when dry, protein-polymer conjugates show altered dynamics, with grafted polymers adsorbing water upon hydration.

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Area of Science:

  • Biophysics
  • Materials Science
  • Polymer Chemistry

Background:

  • Proteins exhibit thermal structural fluctuations crucial for function.
  • Polymer coatings can alter protein properties, but their effect on dynamics is less understood.
  • Water plays a key role in protein flexibility and dynamics.

Purpose of the Study:

  • To investigate protein-polymer conjugate dynamics using neutron scattering.
  • To determine if polymer coatings can substitute for water in promoting protein fluctuations.
  • To compare dynamics in protein-polymer mixtures versus covalently attached conjugates.

Main Methods:

  • Neutron scattering spectroscopy was employed to study relaxation dynamics.
  • Protein-polymer mixtures and conjugates with varying polymer attachments were analyzed.
  • Dynamics were compared in both dry and hydrated states.

Main Results:

  • Protein flexibility was highest in protein-polymer mixtures, exceeding native protein or conjugates.
  • Even in the dry state, conjugates exhibited different dynamics compared to native proteins.
  • Upon hydration, native proteins and conjugates displayed similar dynamics, indicating polymer water adsorption.

Conclusions:

  • Polymer coatings significantly impact protein dynamics, even in the absence of water.
  • Grafted polymers effectively adsorb water, influencing the hydration dynamics of the protein.
  • Protein-polymer conjugates offer a route to modulate protein flexibility and hydration behavior.