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Manual Drainage of the Zebrafish Embryonic Brain Ventricles
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Vortex Dynamics in Trabeculated Embryonic Ventricles.

Nicholas A Battista1, Dylan R Douglas2,3, Andrea N Lane4

  • 1Department of Mathematics and Statistics, 2000 Pennington Road, The College of New Jersey, Ewing Township, NJ 08628, USA. battistn@tcnj.edu.

Journal of Cardiovascular Development and Disease
|January 26, 2019
PubMed
Summary
This summary is machine-generated.

Heart development relies on balanced forces. This study simulated zebrafish heart blood flow, finding that trabeculae shape significantly impacts flow patterns and signaling, influencing heart formation.

Keywords:
cardiac fluid dynamicscavity flowfluid dynamicsheart developmentimmersed boundary methodtrabeculae

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Area of Science:

  • Cardiovascular Science
  • Developmental Biology
  • Biophysics

Background:

  • Heart morphogenesis requires a balance of hemodynamic forces, myocardial activity, and signaling pathways.
  • Intracardial hemodynamics during vertebrate cardiogenesis, especially trabeculation onset, are complex and sensitive to perturbations.
  • Understanding these forces is crucial for deciphering normal and abnormal heart development.

Purpose of the Study:

  • To numerically simulate intracardial fluid flow in developing zebrafish ventricles.
  • To investigate the impact of trabecular morphology and flow dynamics on hemodynamics and signaling.
  • To explore how altered hemodynamics affect chamber morphogenesis and valvulogenesis.

Main Methods:

  • Utilized the immersed boundary method for 2D numerical simulations of fluid flow.
  • Modeled simplified, stationary trabeculated ventricles from zebrafish embryos at various developmental stages.
  • Analyzed flow structures, vortex formation, and shear stress distributions under biologically relevant parameters.

Main Results:

  • Vortex formation was observed in intertrabecular regions for biologically relevant parameters.
  • Trabecular morphology was found to alter intracardial flow patterns, shear stresses, and morphogen gradients.
  • Simulations revealed sensitivity of cardiac flow to changes in morphology and blood rheology.

Conclusions:

  • Trabecular morphology plays a critical role in shaping intracardial hemodynamics.
  • Disturbed blood flow patterns can upregulate Notch1 expression, impacting heart development.
  • Results underscore the need for precise measurements of embryonic heart geometry and blood rheology.