A new bioactive coumestan from the seeds of Psoralea corylifolia

A new coumestan named bavacoumestan D (1), together with five known compounds (2-6), was isolated from EtOAc-soluble extract of seeds of Psoralea corylifolia. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All compounds were evaluated for in vitro inhibitory activity against DGAT1, DGAT2 and α-glucosidase. Among them, compounds 1-2, 5-6 showed potential inhibitory activity on DGAT1 with IC₅₀ values ranging from 52.3 ± 1.3 to 81.0 ± 1.0 μM. Compounds 1-3, 6 displayed the significant inhibitory activity on α-glucosidase with IC₅₀ values ranging from 31.2 to 89.1 μM.[Formula: see text].