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Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging
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Progress in Research on Brain Development and Function of Mice During Weaning.
Wenjie Zhang1, Yueling Zhang2, Yuanjia Zheng3
1The First Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Current Protein & Peptide Science
|January 26, 2019
Summary
Weaning in mice impacts brain development and function, altering tissue morphology and glial cell activity. Understanding these changes is key for neuropsychiatric disease research and drug discovery.
Area of Science:
- Neuroscience
- Developmental Biology
- Animal Models
Background:
- Lactation is crucial for brain development.
- Weaning introduces new dietary and environmental experiences.
- These experiences influence offspring's brain development and behavior.
Purpose of the Study:
- To investigate the effects of weaning on mouse brain development.
- To understand how altered weaning impacts brain morphology and molecular characteristics.
- To explore the potential of weaning as a model for studying neuropsychiatric diseases.
Main Methods:
- Observational studies on mouse offspring during lactation and weaning.
- Analysis of brain tissue morphology and molecular markers.
- Assessment of glial cell activity and behavior.
Main Results:
- Changes in weaning time alter brain tissue morphology and molecular profiles.
- Weaning significantly affects glial cell activity and behavior.
- Offspring show altered responses to food and environment post-weaning.
Conclusions:
- Weaning is a critical period influencing brain development and function in mice.
- Alterations during weaning can lead to lasting changes in brain structure and behavior.
- Mouse models of weaning offer insights into neuropsychiatric disorders and potential therapeutic targets.
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