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Immunohistochemical localization of glutathione peroxidase in ocular tissue
L R Atalla1, A Sevanian, N A Rao
1Estelle Doheny Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles.
Current Eye Research
|October 1, 1988
Abstract:
In this study enzyme glutathione peroxidase was localized in ocular tissue of Lewis rats using the peroxidase antiperoxidase immunohistochemical technique. Antisera to glutathione peroxidase was raised in a rabbit. Immunoreactive glutathione peroxidase was found to be distributed predominantly in the corneal epithelium and endothelium, choroid, inner segment of photoreceptors and retinal pigmented epithelium. Its presence in these sites suggests an adaptation to oxidative stress where this antioxidant enzyme along with other antioxidant systems serves to prevent damage.