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Related Concept Videos

The Precise Definition of a Limit01:27

The Precise Definition of a Limit

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Understanding the formal definition of a limit is essential for precise mathematical analysis. This concept allows us to rigorously determine how a function behaves near a particular point without relying on ambiguous notions such as "getting close." The ε-δ definition plays a foundational role in calculus, ensuring analytical clarity and logical consistency in limit evaluation.The formal definition states that the limit of a function f(x) as x approaches a is L, written asif for...
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Expected Value01:15

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The expected value is known as the "long-term" average or mean. This means that over the long term of experimenting over and over, you would expect this average. The expected average is represented by the symbol μ. It is calculated as follows:
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Limiting Reactant02:27

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The relative amounts of reactants and products represented in a balanced chemical equation are often referred to as stoichiometric amounts. However, in reality, the reactants are not always present in the stoichiometric amounts indicated by the balanced equation.
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Determination of Expected Frequency01:08

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Suppose one wants to test independence between the two variables of a contingency table. The values in the table constitute the observed frequencies of the dataset. But how does one determine the expected frequency of the dataset? One of the important assumptions is that the two variables are independent, which means the variables do not influence each other. For independent variables, the statistical probability of any event involving both variables is calculated by multiplying the individual...
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The Number e as a Limit01:29

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The number e is a fundamental constant in calculus, playing a central role in describing continuous change, particularly exponential growth. It is most naturally defined through its relationship with the natural logarithm, which is the inverse of the exponential function with base e. This relationship allows e to be characterized using basic principles of differentiation rather than as an arbitrary numerical constant.A key property of the natural logarithm function, ln x, is that its derivative...
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Uncertainty in Measurement: Accuracy and Precision03:37

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Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
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Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
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Precision oncology: as much expectations as limitations.

Vitor Fiorin Vasconcellos1, Leandro Machado Colli2, Ahmad Awada3

  • 1Clinical Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

Ecancermedicalscience
|January 26, 2019
PubMed
Summary
This summary is machine-generated.

Next-generation sequencing (NGS) advances personalized cancer therapy. However, only a small fraction of solid tumors are currently eligible for targeted drugs, despite clinical benefits and cost-effectiveness analyses.

Area of Science:

  • Oncology
  • Genomics
  • Pharmacology

Background:

  • Recent advancements in next-generation sequencing (NGS) platforms have led to reduced costs and increased accessibility.
Keywords:
DNAmolecular diagnostic techniquesmolecular targeted therapyprecision medicinesequence analysis

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  • There is growing investment and research into novel cancer targets and corresponding targeted therapies.
  • Personalized anti-cancer therapies are generating significant global interest.