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Updated: Jan 30, 2026
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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
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The Tumor Microenvironment in Post-Transplant Lymphoproliferative Disorders
Lukas Marcelis1, Thomas Tousseyn2,3
1Department of Imaging and Pathology, Translational Cell and Tissue Research Lab, KU Leuven, Herestraat 49 - O&N IV, 3000, Leuven, Belgium.
Summary
Post-transplant lymphoproliferative disorders (PTLDs) involve complex tumor microenvironment (TME) interactions. Understanding PTLD TME is crucial for advancing cancer research and treatments for other malignancies.
Area of Science:
- Immunology
- Oncology
- Transplantation Medicine
Background:
- Post-transplant lymphoproliferative disorders (PTLDs) are lymphoproliferative lesions following transplantation.
- The tumor microenvironment (TME) significantly influences PTLD development and progression.
Purpose of the Study:
- To review current knowledge on PTLD tumor microenvironment (TME) composition.
- To explore the interplay of factors influencing PTLD development.
Main Methods:
- Literature review of PTLD studies focusing on TME.
- Analysis of the impact of graft, immunosuppression, Epstein-Barr virus (EBV), and donor immune cells on PTLD TME.
Main Results:
- PTLD TME is shaped by chronic antigen presentation from the graft.
- Immunosuppressive therapy and Epstein-Barr virus (EBV) play critical roles in PTLD pathogenesis.
- Donor-derived immune cells within the graft contribute to the PTLD microenvironment.
Conclusions:
- PTLDs serve as a valuable model for studying cancer-microenvironment interactions.
- Findings in PTLD TME may offer insights applicable to other malignancies, including solid tumors.
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