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Updated: Jan 30, 2026

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
Rethinking Glioblastoma Therapy: MDA-9/Syntenin Targeted Small Molecule
Swadesh K Das1,2,3, Devanand Sarkar1,2,3, Webster K Cavenee4
1Department of Human and Molecular Genetics , Virginia Commonwealth University, School of Medicine , Richmond , Virginia 23298 , United States.
Abstract:
Effective therapies for glioblastoma multiforme (GBM) are not currently available. A small molecule has been identified using fragment-based drug-discovery guided by NMR that targets important protein-protein interactions controlling GBM invasion and pathogenicity. This first generation drug displays excellent pharmacokinetic properties, passes through the blood-brain barrier and is effective in preclinical animal models of GBM, particularly when combined with radiation therapy.
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