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Peripheral leukocytes in psoriasis.

C H Liu1, M R Ji, X Fang

  • 1Department of Dermatology, Huashan Hospital, Shanghai Medical University, People's Republic of China.

International Journal of Dermatology
|November 1, 1988
PubMed
Summary
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Psoriasis patients often show low T-lymphocyte counts, particularly those with severe skin conditions. Treatments like antineoplastic drugs and immunosuppressants worsen T-lymphocytopenia, potentially causing disease recurrence.

Area of Science:

  • Immunology
  • Dermatology
  • Hematology

Background:

  • Psoriasis is a chronic inflammatory skin condition with varying clinical presentations.
  • Understanding immune cell dynamics, specifically white blood cell (WBC) counts and lymphocyte subsets, is crucial for managing psoriasis.

Observation:

  • Analysis of WBC counts and lymphocyte morphology, including acid alpha-naphthyl acetate esterase (ANAE) activity, was performed in psoriatic patients.
  • Patients with psoriasis erythrodermica and psoriasis pustulosa exhibited significantly increased total WBC and polymorphonuclear leukocyte counts.

Findings:

  • Lymphocytopenia, characterized by a reduction in lymphocytes, was observed across all psoriasis types.
  • A notable decrease in T-lymphocytes (T-lymphocytopenia) was a consistent finding in psoriatic patients.

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  • The use of antineoplastic drugs and immunosuppressants exacerbated T-lymphocytopenia.

    • Implications:

    • Worsened T-lymphocytopenia may contribute to disease recurrence and treatment resistance in psoriasis.
    • These findings suggest that antineoplastic drugs and immunosuppressants may not be optimal first-line treatments for psoriasis.