[Research progress on animal models relevant to porto-sinusoidal vascular disease]

In recent years, the European Society for Vascular Surgery has proposed the concept of porto-sinusoidal vascular disease (PSVD) based on idiopathic non-cirrhotic portal hypertension (INCPH), thereby expanding the scope of these disease conditions and creating understanding for their natural history. However, research on the pathogenesis of this disease has progressed slowly due to the lack of corresponding animal models. A review of previous animal models that meet the definition of porto-sinusoidal vascular disease reveals that none of these models have progressed to develop cirrhosis. Nine models exhibited elevated portal vein pressure, while sixteen models showed histological manifestations related to portal hypertension. This summary aims to lay the foundation for future research.